Brain phantom trains analysis software

The authentic reproduction of characteristic nerve structures in the brain is therefore important for "training" the dMRI analysis software. The use of 3D printing makes it possible to create diverse and complex designs that can be modified and customised. The brain phantoms thus depict areas in the brain that generate particularly complex signals and are therefore difficult to analyse, such as intersecting nerve pathways. In order to calibrate the analysis software, the brain phantom is therefore examined using dMRI and the measured data is analysed as in a real brain. Thanks to 3D printing, the design of the phantoms is precisely known and the results of the analysis can be checked. MedUni Vienna and TU Wien were able to show that this works as part of the joint research work. The phantoms developed can be used to improve dMRI, which can benefit the planning of operations and research into neurodegenerative diseases such as Alzheimer's, Parkinson's and multiple sclerosis.


Despite the proof of concept, the team still faces challenges. The biggest challenge at the moment is scaling up the method: "The high resolution of two-photon polymerisation makes it possible to print details in the micro- and nanometre range and is therefore very suitable for imaging cranial nerves. At the same time, however, it takes a correspondingly long time to print a cube several cubic centimetres in size using this technique," explains Chalupa-Gantner. "We are therefore not only aiming to develop even more complex designs, but also to further optimise the printing process itself."


Publication: Advanced Materials Technologies
Toward Printing the Brain: A Microstructural Ground Truth Phantom for MRI;
Michael Woletz, Franziska Chalupa-Gantner, Benedikt Hager, Alexander Ricke, Siawoosh Mohammadi, Stefan Binder, Stefan Baudis, Aleksandr Ovsianikov, Christian Windischberger, Zoltan Nagy;


Medical University of Vienna - short profile
Medical University Vienna (MedUni Vienna) is one of the longest-established medical education and research facilities in Europe. With almost 8,000 students, it is currently the largest medical training centre in the German-speaking countries. With 6,000 employees, 30 departments and two clinical institutes, 12 medical theory centres and numerous highly specialised laboratories, it is also one of Europe's leading research establishments in the biomedical sector.

TU Wien - short profile
The TU Wien is Austria's largest research and educational institution in the field of technology and natural sciences. More than 4,000 scientists conduct research in five research priorities at eight faculties on "Technology for People". The content of the degree programmes offered is derived from excellent research. Almost 26,000 students benefit from around 60 degree programmes. As a driver of innovation, TU Wien strengthens the business location, facilitates cooperation and contributes to the prosperity of society.

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