From the April 2022 issue of HealthCare Business News magazine
HCB News (www.dotmed.com/news) is a leading news source for cardiology current events. In this section we recap some of the highest-impact stories we’ve published over the last six months.
For more stories like these, visit our news site and click “Cardiology” in the red navigation bar at the top of the screen. Registering for our online news is completely free.
New Zealand scientists design pacemaker that 'reverses' heart failure
In February, scientists at the University of Auckland are planning to recruit patients in New Zealand for a trial to assess a pacemaker designed to reestablish the heart’s naturally irregular beat and reverse heart failure.
Pacemakers today pace the heart metronomically, which creates a steady, even pace. This, however, is different from a healthy individual’s or animal’s heartbeat, which is constantly on the move and modulated by breathing.
The new pacemaker is designed to ensure this by using inhalation and exhalation signals to communicate with the body and pace the heart up when breathing in and down when breathing out. By creating an irregular heartbeat versus a steady, paced one, the solution improves the ability of the heart to pump blood throughout the body by 20% and essential contractile proteins reemerge and realign.
The device was developed with unique analogue pacemaker technology from Ceryx Medical, which is funding the first human clinical trial on its efficiency. It has already been tested on sheep. The human trial will commence in July 2022, according to professor Julian Paton, a lead researcher and director of Manaaki Manawa, the Centre for Heart Research at the University of Auckland.
"We have found a 20% improvement in cardiac output before any medication is used in heart failure. This reflects at least twice what is seen with conventional pacing/optimal medication. Our pacing methodology also reduces sleep apnea and improves blood flow to organs. It resets the baroreceptor reflex, which is an excellent prognostic indicator. And unlike conventional pacing, our variable pacing reverses the damage to the heart cells," he told HCB News.
The loss of an irregular heartbeat is an early sign of cardiovascular disease. Patients can take drugs to feel better, but they do not address or fix the damaged tissues, which are not contracting as efficiently.
The device was successful in a study of rats, and more recently, in a large animal model of heart failure. The human trial will be led by Dr. Martin Stiles, a cardiologist from Waikato Hospital in Hamilton, New Zealand. Patients will be recruited later this year for the trial, which is supported by Ceryx Medical, a startup company that owns the IP on the unique electronics within the bionic pacemaker.
